Effects of 6 CNS Stimulants

Below are six representative CNS stimulants and their primary effects.

• Amphetamine: Enhances concentration and attention, effective for ADHD.
• Methamphetamine: Produces strong arousal and euphoria but highly addictive.
• Cocaine: Rapid onset, induces euphoria and arousal but short duration.
• Caffeine: Mild stimulant effect, suppresses drowsiness.
• Nicotine: Provides focus and relaxation but highly addictive.
• Modafinil: Gentle stimulant effect, low addiction potential, long duration.

Mechanism of Action (Detailed, Clear, Results)

Each stimulant affects neurotransmitters differently, leading to changes in arousal and concentration.

• Amphetamine: Promotes dopamine and norepinephrine release, activates reward system. Results in improved attention and focus.
• Methamphetamine: Induces stronger dopamine release than amphetamine, creating intense pleasure.
• Cocaine: Inhibits dopamine reuptake. Dopamine accumulates in synaptic cleft, creating euphoria.
• Caffeine: Blocks adenosine receptors, preventing brain from feeling "sleepy".
• Nicotine: Stimulates acetylcholine receptors, indirectly releasing dopamine. Balances focus and pleasure.
• Modafinil: Gently inhibits dopamine reuptake, maintaining wakefulness longer.

Recommended Supplements for Combination

• L-Tyrosine: Dopamine precursor. Helps maintain focus and motivation.
• Magnesium: Reduces neural excitation, alleviates stimulant-induced tension.
• Omega-3 Fatty Acids: Reduces brain inflammation, improves neurotransmission efficiency.
• B Vitamins: Supports energy metabolism and neurotransmission.
• CDP Choline: Acetylcholine precursor, supports memory and concentration.

Compatible Medications: Benefits, Drawbacks, and Recommended Supplements

Example: Modafinil + L-Tyrosine
Enhances focus while minimizing side effects.

Example: Amphetamine + Magnesium
Effective in reducing neural hypersensitivity and tension.

Drawbacks: Careful attention needed for drug interactions. Dangerous when heart rate and blood pressure increases overlap.

Recommended Supplements: Ashwagandha, Theanine (promotes relaxation), Rhodiola Rosea (combats fatigue), etc.

Supplements to Prevent Post-MDMA Depression (Why They Work)

MDMA causes massive serotonin release, leading to temporary "serotonin depletion" and potential severe depression the next day.

Recovery Supplements and Their Effects

• 5-HTP: Serotonin precursor. Replenishes depleted serotonin.
• Vitamin B6: Helps convert 5-HTP to serotonin.
• Magnesium: Reduces neural excitation and muscle tension.
• Antioxidants (ALA, NAC): Protects brain from oxidative stress caused by MDMA.

Why They Work: By supplementing neurotransmitter precursors and protecting the brain from stress, they help reduce the "comedown" effect.